What causes High Blood Pressure?

High Blood pressure is almost always caused by narrowing of your arteries by a plaque or calcium buildup.   It’s like putting your thumb over a garden hose.  You reduce the hose opening and you get a lot more water pressure.
Your arteries work the same way.  Block any artery and the blood pressure goes up behind it.  Block it enough and you stop blood flow.  That’s a heart attack or stroke.

As we get older we only make 15% of the
Nitric Oxide we made when we were 20 year old.

If you have sufficient Nitric Oxide,
your body will regulate it’s own blood pressure. 

But as we grow older, our body loses the ability to make Nitric Oxide and our arteries begin to block up.  In fact, by the time we’re 60 years old we are only making 15% of the Nitric Oxide we made when we were 20 and it’s in our 60’s that High Blood pressure and Cardiovascular problems start causing heart attacks and strokes.  


Dr. Rainer Böger M.D.

Professor of Clinical Pharmacology
Director of the Institute of Clinical Pharmacology and Toxicology
Director Clinical Trial Center North

Hamburg University Medical Center, Germany

Dr. Rainer Böger received his medical training at Hannover Medical School in Hannover, Germany. He received his postgraduate training in Internal Medicine and Pharmacology both in Hannover and at Stanford University School of Medicine in Stanford, CA.

Dr. Böger’s scientific work centers on the early diagnosis and prevention of cardiovascular related diseases. Dating back to the beginning of his medical career, Dr. Böger has been heavily involved in the research and treatment of cardiovascular related diseases. In 1991, while working closely with pharmaceutical drug companies to develop treatments that could combat and alleviate such diseases, he became highly interested in nitric oxide (NO) and its effects on the vascular system.

Dr. Böger has dedicated 22 years of academic research in basic science and clinical studies related to L-arginine and its influence on the body’s ability to produce NO. His major achievements are the discovery that ADMA (asymmetric dimethylarginine) is a risk marker of vascular disease and the utilization of L-arginine to prevent vascular dysfunction and disease.

Dr. Böger collaborates with renowned institutions like the Mayo Clinic and Stanford University Medical Center. He has documented his knowledge in more than 200 scientific articles, of which 130 exclusively cover the roles of ADMA and L-arginine in cardiovascular and metabolic diseases.

“With 22 years of basic and applied clinical research experience, I have made it my mission to use the discovery of these biological mechanisms to develop novel ways of enhancing cardiovascular health. As a clinical physician, I have treated patients who suffered from severe lack of blood flow to the legs, and it is this experience that has inspired me to research the benefits of L-arginine and its affect on tissue blood flow.

When using L-arginine as a dietary supplement, there are a few caveats that need to be considered. Restoring nitric oxide formation with L-arginine needs to be maintained around the clock. L-arginine, however, has a short residence time in blood; in less than 1 hour, half is already spent. Only when L-arginine is combined with L-citrulline is it possible to provide prolonged elevations of L-arginine in the blood stream.

Furthermore, cardiovascular health is a refined balance in which the endothelial cells interact with oxidative factors, blood platelets and the coagulation system, and transcriptional regulation of cell growth and development. Thus, additional components can interact with L-arginine to promote cardiovascular health on a multifactorial level.

With its unique blend of l-arginine and other supportive ingredients, it is my experience that Synergy’s ProArgi-9+ provides an optimized way to enhance your cardiovascular system compared to other nutritional supplements on the market.” Dr. Rainer Boger

Nitric oxide (NO) is one of the smallest molecules in the human body, but like oxygen (O2), it plays an extraordinarily important role for maintaining a healthy life. Nitric oxide keeps arteries wide, so that oxygen can be easily delivered to all the organs where it is needed.

NO is produced, in many different cell types throughout the body, from the amino acid precursor, L-arginine. The conversion of Larginine to NO makes it a very unique amino acid that is of essential nutritional importance.

The site of NO production determines its biological effects:

  • In the arteries, NO keeps blood flow high and keeps arteries smooth and flexible.
  • In the gut, NO enhances intestinal function and prevents obstipation.
  • In the airway system, NO helps keep air flowing freely to the lungs.
  • In the brain and nervous system, NO decreases pain sensation and contributes to good memory formation.

By enhancing NO production, L-arginine is able to promote all of these effects. Thus, it is no wonder that such a huge diversity of organ functions are positively affected by L-arginine supplementation. Some people may call it a wonder, but I call it the science behind L-arginine.

Indeed, people with all different kinds of health concerns have reported improvements in their health status while on regular L-arginine supplementation.
One true fact needs to be considered, though, when one contemplates about this broad variety of health benefits: None of them can be achieved if L-arginine levels in blood are not successfully elevated above “normal” for 24/7. Only combinations of L-arginine with L-citrulline have the biological potential to achieve this goal, and only ProArgi9+ has been scientifically confirmed to do this.

This product’s success is also explained by some of its additional ingredients that support ProArgi9+’s effects on stimulating NO:

  • Resveratrol, the powerful antioxidant contained in red wine, supports the biological actions of NO on cells by reducing toxic oxygen radicals that may not only destroy the NO molecule, but also cause severe harm to the cell itself.
  • Vitamin D3 has been known as a vitamin that is good for bone health; however, medical research in the last few years has revealed that it is also an important regulator of glucose and fat metabolism, of blood vessel function and cell growth.

Thus, the power of ProArgi9+ is in the quality and science coming with its ingredients

A few of Dr. Boger’s research papers

Böger RH. J.Nutr. 2007_137_1650S-1655S
Schwedhelm E, et al. Br J Clin Pharmacol. 2008_65_51-9
Schutte AE, et al. Eur J Endocrinol. 2010_162_525-33
Böger RH, et.al. Circulation 1998_98_1842-1847 (1)
Kielstein JT, et.al. J.Am.Soc.Nephrol. 1999_10_594-600
Chan JR, et.al. Arterioscler.Thromb.Vasc.Biol. 2000_20_1040-1046
Böger RH, et.al. Circ.Res. 2000_87_99-105
Kielstein JT, et.al. J.Am.Soc.Nephrol. 2002_13_170-176
Böger RH. Cardivasc.Res. 2003_59_824-833
Böger RH. J.Nutr. 2004_134_ 2842S-2847S
Krempl TK, et.al. Eur.HeartJ. 2005_26_1846-1851
Böger RH. Crit Care. 2006_10_169
Jacobi J, et.al. Am J Physiol Heart Circ Physiol 2008_294_1058-1066
Maas R, et al. Stroke 2009_40_2715-9

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